Peer-reviewed veterinary case report
Anti-edema effect of epigallocatechin gallate on spinal cord injury in rats.
- Journal:
- Brain research
- Year:
- 2013
- Authors:
- Ge, Rui et al.
- Affiliation:
- Department of Orthopaedics · China
- Species:
- rodent
Abstract
Recent studies indicated that epigallocatechin gallate (EGCG) had neuroprotective effects on spinal cord injury (SCI).The current study was performed to determine the anti-edema effect of EGCG after SCI in rats. EGCG (100 mg/kg, i.p.) was administered to rats immediately following SCI. It was found that EGCG (100 mg/kg) could significantly reduce spinal cord water content. In addition, EGCG (100mg/kg) significantly reduced the expression of aquaporin-4(AQP4) and glial fibrillary acidic protein (GFAP) level at 24, 48 and 72h after injury, but it did not have this effect at 12 h after injury. The changes of AQP4 and GFAP protein induced by EGCG (100 mg/kg) treatment were accompanied by a reduction of spinal cord edema. Our results indicated that EGCG (100 mg/kg) could reduce spinal cord edema after SCI, which could be correlated with the down-regulation the expression of AQP4 and GFAP protein level after SCI.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23831998/