Peer-reviewed veterinary case report
Anti-inflammatory activity of alkanoids and triterpenoids from Trichodesma amplexicaule Roth.
- Journal:
- Phytomedicine : international journal of phytotherapy and phytopharmacology
- Year:
- 2006
- Authors:
- Singh, B et al.
- Affiliation:
- Department of Botany · India
- Species:
- rodent
Abstract
The phytochemical investigation of Trichodesma amplexicaule guided by bioassay, to isolation of triterpenoids and aliphatic phytoconstituents. To evaluate the anti-inflammatory activities of isolated phytoconstituents, models with carrageenan-induced acute arthritis and complete Freund's adjuvant (CFA)-induced chronic arthritis in rats were conducted. The investigated results showed that alkanoic acid significantly inhibited the carrageenan-induced acute arthritis. Moreover, alkane also supressed the development of chronic arthritis induced by CFA. It has been reported that alkane was the major phytoconstituent (1.03 +/- 0.00135%) in in vivo studies.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16428021/