Peer-reviewed veterinary case report
Anti-Inflammatory and Antioxidative <i>N</i>-Acetyldopamine Dimers from Adult <i>Vespa velutina auraria</i> Smith.
- Year:
- 2024
- Authors:
- Liu CH et al.
- Affiliation:
- College of Pharmacy · China
Abstract
One undescribed fatty glyceride (<b>1</b>), two unreported <i>N</i>-acetyldopamine dimers (<b>2</b> and <b>3</b>), and four known structurally diverse <i>N</i>-acetyldopamine dimers were isolated from adult <i>Vespa velutina auraria</i> Smith. Their structures were elucidated based on a comprehensive analysis of spectroscopic data, HRESIMS, and NMR calculations with ML_J_DP4, and the absolute configurations of <b>2</b> and <b>3</b> were determined via ECD calculations. Regarding their bioactivities, compounds <b>5</b> and <b>6</b> can inhibit the production of NO. Moreover, compounds <b>3</b>, <b>5</b> and <b>7</b> showed stronger antioxidant activity than the positive control (VC) at 14 μg/mL. A network pharmacology study was used to explore the potential bioactive mechanisms. In addition, a docking study of anti-inflammatory and antioxidative compounds was also performed.
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Search related cases →Original publication: https://europepmc.org/article/MED/39598834