Peer-reviewed veterinary case report
Anti-inflammatory and neuroprotective effects of auraptene, a citrus coumarin, following cerebral global ischemia in mice.
- Journal:
- European journal of pharmacology
- Year:
- 2013
- Authors:
- Okuyama, Satoshi et al.
- Affiliation:
- Department of Pharmaceutical Pharmacology · Japan
- Species:
- rodent
Abstract
Cerebral ischemia causes delayed neuronal cell death in the hippocampus resulting in sequential cognitive impairments. Hyper-activated inflammation following ischemia is one of the etiologies for delayed neuronal cell death. In the present study, using a transient global ischemia mouse model, we showed that auraptene (AUR), a citrus coumarin, effectively inhibited microglia activation, cyclooxygenase-2 expression by astrocytes, and neuronal cell death in the hippocampus following ischemic insults. These results suggest that AUR acts as a neuroprotective agent in the ischemic brain, which may be mediated by suppression of the inflammatory response.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23219792/