Peer-reviewed veterinary case report
Anti-Mullerian hormone levels in male dogs by neuter and cryptorchid
By Prapaiwan, N et al.·Published in Theriogenology·2023·Department of Clinical Sciences and Public Health·View original on PubMed →
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Original publication title: Anti-Müllerian hormone levels in serum and testes of male dogs: relations with neuter status and bilateral abdominal cryptorchidism.
- Species:
- dog
Plain-English summary
A study found that male dogs with a condition called bilateral abdominal cryptorchidism (where one or both testicles fail to descend) had higher levels of a hormone called Anti-Müllerian hormone (AMH) in their blood compared to healthy intact dogs. This means that measuring AMH levels could help veterinarians quickly identify dogs with this condition. In contrast, neutered dogs had very low AMH levels. The researchers suggest that testing for AMH could be a useful tool in diagnosing this issue in male dogs.
People also search for: dog testicle problems · cryptorchidism in dogs · neutered dog hormone levels
Abstract
Anti-Müllerian hormone (AMH) analysis has contributed to new information in the reproductive endocrinology of domestic animals, due to clinically available diagnostic tools. An accurate and rapid diagnostic method to distinguish between neutered and bilateral abdominal cryptorchid dogs is needed in veterinary practice. Therefore, this study uses an enzyme-linked immunosorbent assay to evaluate the clinical relevance of AMH analysis in peripheral blood as a diagnostic tool for dogs with suspected bilateral abdominal cryptorchidism. The possible alteration of the AMH localization in testicular tissue caused by this pathologic condition was also investigated using immunohistochemistry. Male dogs were divided into three groups of healthy intact (n = 14), healthy castrated (n = 14), and bilateral abdominal cryptorchid (n = 14) dogs. The results demonstrated a higher level of serum AMH in the cryptorchid group compared to the intact group (P < 0.01), while serum AMH levels of all castrated dogs were below the limit of detection (<0.05 ng/mL). Moreover, the percentage of positive AMH immunostaining of the intact group was less than that of the cryptorchid group (P < 0.01). A significantly positive correlation was found between serum AMH concentration and localization in testicular tissues (r = 0.93, P < 0.01). Our findings suggest that AMH levels in the peripheral blood could be used as an alternative and rapid screening method for detecting dogs with abdominal cryptorchidism.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37352559/