Peer-reviewed veterinary case report
Anti-NDV activity of baicalin from a traditional Chinese medicine in vitro.
- Journal:
- The Journal of veterinary medical science
- Year:
- 2016
- Authors:
- Jia, Yan et al.
- Affiliation:
- Jiaxing Vocational Technical College · China
Abstract
The purpose of this study was to investigate the anti-Newcastle disease virus (NDV) activities of baicalin from Scutellaria baicalensis, a Traditional Chinese Medicine in vitro. Chicken embryo fibroblasts (CEFs) were infected with NDV, and quantitative analysis of apoptotic cells was performed using flow cytometry. Cytotoxicity and anti-viral activities of baicalin were studied using the MTT method. The results showed that the maximal safe concentrations of baicalin to CEFs was 1 × 2(-2) mg/ml. Baicalin could directly kill NDV, inhibit the infectivity of NDV to CEF and block intracellular NDV. It inhibited the apoptosis of NDV-infected CEFs and suppressed the spread of NDV. These results indicate that baicalin has strong anti-NDV activity and has the potential for use as components of an antiviral drug.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/26902693/