Peer-reviewed veterinary case report
Dog with pemphigus vulgaris had autoantibodies to plakin
By Olivry, T et al.·Published in Veterinary pathology·2000·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Anti-plakin and desmoglein autoantibodies in a dog with pemphigus vulgaris.
- Species:
- dog
Plain-English summary
A 14-year-old Labrador retriever was brought in with painful sores on its skin and mouth, which raised concerns about a serious autoimmune condition called pemphigus vulgaris. Tests showed that the dog had specific autoantibodies attacking its skin cells, but a thorough examination did not find any tumors or cancers. The diagnosis was confirmed as pemphigus vulgaris, a condition where the immune system mistakenly attacks the skin. Treatment options typically include immunosuppressive medications to help manage the symptoms and improve the dog's quality of life.
People also search for: dog skin sores treatment · Labrador pemphigus vulgaris · autoimmune skin disease in dogs
Abstract
Paraneoplastic pemphigus was suspected in a 14-year-old Labrador retriever because of mucocutaneous erosions, microscopic suprabasal acantholysis, and keratinocyte apoptosis. In this patient, circulating IgG autoantibodies recognized plakin (envoplakin, periplakin) and desmoglein (desmoglein-1 and -3) antigens. Necropsy, however, failed to confirm the concurrent existence of hematopoietic or solid neoplasia. The diagnosis of pemphigus vulgaris therefore was proposed. This study illustrates that such a combination of clinicopathologic lesions and plakin/desmoglein-specific autoantibodies is not restricted to canine paraneoplastic pemphigus but can also be detected in another form of suprabasal pemphigus.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/11055881/