Peer-reviewed veterinary case report
Antiarrhythmogenic and antioxidant effect of the flavonoid dioclein in a model of cardiac ischemia/reperfusion.
- Journal:
- Planta medica
- Year:
- 2006
- Authors:
- Vianna, Heloisa R et al.
- Affiliation:
- Departamento de Fisiologia e Biofí · Brazil
- Species:
- rodent
Abstract
The antiarrhythmogenic effect of the flavonoid dioclein on myocardial ischemia/reperfusion was investigated in isolated perfused rat hearts. Low concentrations of dioclein (30-300 nM) induced a reduction of arrhythmias observed during the reperfusion period. Dioclein also preserved the diastolic tension after reperfusion without affecting the systolic tension. In addition, dioclein (150 nM) dramatically reduced the formation of reactive oxygen species (ROS) observed during reperfusion in hearts. In conclusion, dioclein acts as a potent antiarrhythmogenic and antioxidant drug with an excellent protective effect during reperfusion of ischemic hearts.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16557469/