Peer-reviewed veterinary case report
N-acetylcysteine kills bacteria in dog ear infections
By May, Elizabeth R et al.·Published in Veterinary dermatology·2016·University of Tennessee, United States·View original on PubMed →
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Original publication title: Antibacterial effect of N-acetylcysteine on common canine otitis externa isolates.
- Species:
- dog
Plain-English summary
A study tested N-acetylcysteine (NAC) for its ability to fight bacteria causing ear infections in dogs, specifically otitis externa. Researchers found that NAC effectively inhibited several common bacteria, including Staphylococcus and Pseudomonas, at concentrations between 5 to 20 mg/mL. This suggests that NAC could be a promising new treatment option for dogs suffering from these types of ear infections, especially those resistant to other medications. While further research is needed, the initial results are encouraging for improving ear health in affected dogs.
People also search for: dog ear infection treatment · N-acetylcysteine for dogs · otitis externa in dogs · dog ear infection bacteria
Abstract
BACKGROUND: N-Acetylcysteine (NAC) has the potential to be a useful therapeutic agent for the treatment of otitis externa due to its antimicrobial and mucolytic properties, as well as its ability to disrupt bacterial biofilm. HYPOTHESIS/OBJECTIVES: To determine the antibacterial activity of NAC against common bacterial isolates associated with canine otitis externa. ANIMALS: Twenty two isolates from canine clinical cases of otitis externa were identified and tested, including five Staphylococcus pseudintermedius, six Pseudomonas aeruginosa, five Corynebacterium spp. and six β-haemolytic Streptococcus spp. isolates. METHODS: Each isolate was grown on blood agar for 24 h and transferred to Mueller Hinton Broth (MHB) to achieve a final concentration of 5 × 10(5)  CFU/mL. NAC was diluted in MHB to a starting concentration of 160 mg/mL and serial two-fold microdilution assays were performed in triplicate with negative controls for all isolates tested. Concentrations of NAC tested ranged from 0.125 to 80 mg/mL. A 50 μL volume of bacterial suspension was used to inoculate each well. RESULTS: The minimum inhibitory concentration (MIC) of NAC for all isolates tested ranged from 5 to 20 mg/mL. CONCLUSIONS AND CLINICAL RELEVANCE: N-Acetylcysteine inhibits clinically relevant and drug resistant bacteria in vitro, and has potential for use as a novel agent for treatment of otitis externa.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27122224/