Peer-reviewed veterinary case report
Silver nanoparticles reduce ear infection biofilms in dogs
By Seo, Mimi et al.·Published in Veterinary medicine and science·2021·Department of Veterinary Internal Medicine, South Korea·View original on PubMed →
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Original publication title: Antibiofilm activity of silver nanoparticles against biofilm forming Staphylococcus pseudintermedius isolated from dogs with otitis externa.
- Species:
- dog
Plain-English summary
A group of dogs with ear infections caused by a bacteria called Staphylococcus pseudintermedius were treated with silver nanoparticles (tiny particles of silver known for their ability to fight germs). The treatment showed promising results, significantly reducing the bacteria's ability to form a protective biofilm, which can make infections harder to treat. At higher concentrations, the silver nanoparticles helped break down the biofilm, allowing for better treatment outcomes. This suggests that silver nanoparticles could be a helpful option for treating ear infections in dogs.
People also search for: dog ear infection treatment · silver nanoparticles for dogs · Staphylococcus pseudintermedius in dogs
Abstract
BACKGROUND: Silver nanoparticles (AgNPs) are known to possess antimicrobial properties. Although the antibiofilm activity of AgNPs has been demonstrated in humans, this activity has not yet been elucidated in veterinary medicine. OBJECTIVES: The purpose of this study was to evaluate the antibiofilm activity of silver nanoparticles against Staphylococcus pseudintermedius. METHODS: Ten isolates of S. pseudintermedius obtained from dogs with otitis externa were treated with AgNPs, and the antibiofilm activity was measured using a modified microtiter plate and Congo red agar (CRA) method and scanning electron microscopy. RESULTS: AgNPs displayed a significant dose-dependent antibiofilm activity and reduced biofilm formation at concentrations of 20 and 10 µg/ml (p < 0.05). S. pseudintermedius exposed to 20 µg/ml of AgNPs formed less bacterial slime compared to the controls on CRA plates. Scanning electron micrographs showed that the biofilm had few individually scattered cells along its surface when treated with AgNP concentrations of 20 and 10 µg/ml. Untreated surfaces showed an aggregated biofilm. CONCLUSIONS: Our results suggested that AgNP may be a valuable alternative antibiofilm agent for canine otitis externa.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34156766/