Peer-reviewed veterinary case report
Antibiotic resistance and treatment options for dog urinary
By Lee, Da-Eun et al.·Published in Frontiers in veterinary science·2024·Department of Veterinary Internal Medicine, South Korea·View original on PubMed →
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Original publication title: Antibiotic efficacy and resistance patterns of urinary tract infection-causing bacteria in dogs and resistome of multidrug-resistantvia whole genome sequencing in South Korea.
- Species:
- dog
Plain-English summary
A group of dogs with urinary tract infections (UTIs) was studied to see how well different antibiotics worked against the bacteria causing their infections. Many of the bacteria were found to be resistant to common antibiotics, making treatment difficult. However, fosfomycin showed promise; two dogs treated with it had negative urine cultures and improved symptoms. This research highlights the need for veterinarians to consider antibiotic resistance when treating UTIs in dogs, especially those with recurring infections.
People also search for: dog urinary tract infection treatment · antibiotic resistance in dogs · fosfomycin for dog UTI · recurrent UTI in dogs · dog urine culture test
Abstract
Bacterial urinary tract infections (UTIs) are prevalent in dogs and necessitate antibiotic intervention. However, the emergence of multidrug-resistant (MDR) bacteria poses significant challenges to antibiotic therapy. Although fosfomycin has been demonstrated to achieve and maintain high concentrations in urine, suggesting its potential for treating UTIs in dogs, its efficacy and the resistance profiles of urinary pathogens from canine UTIs remain elusive. Therefore, this study was conducted to investigate the antibiotic susceptibility of bacterial pathogens isolated from companion dogs with UTIs, with a particular focus on their susceptibility and resistance to fosfomycin. A total of 70 isolates from urine samples were analyzed, of which( = 18),( = 9),( = 5), and( = 5) were predominant. Resistance to erythromycin was most prevalent (94.59%), followed by clindamycin (91.89%) and ampicillin (78.37%), whereas the lowest resistance rate was observed for amikacin (5.40%). Resistance to fosfomycin was observed in 15 out of the 37 predominant isolates (40.54%), including allisolates (100%). All isolates, except 4strains, were categorized as MDR (33 out of 37; 89.18%). The resistance rates for amoxicillin/clavulanic acid and trimethoprim-sulfamethoxazole, which are common first-line antibiotics for canine UTIs, were 48.64 and 56.75%, respectively. Whole-genome sequencing ofisolates, which exhibited high resistance to fosfomycin, revealed multiple antibiotic resistance genes, with chromosomalpresent in all isolates. Among the 27 dogs with recurrent infection included in this study, 2 were administered fosfomycin, resulting in clinical remission, as evidenced by negative urine culture tests. Overall, this study is the first to demonstrate the importance of assessing fosfomycin resistance profile for optimal treatment of canine UTIs, particularly in cases involving MDR strains.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39606651/