Peer-reviewed veterinary case report
Antibodies to a novel leptospiral protein, LruC, in the eye fluids and sera of horses with Leptospira-associated uveitis.
- Journal:
- Clinical and vaccine immunology : CVI
- Year:
- 2012
- Authors:
- Verma, Ashutosh et al.
- Affiliation:
- Department of Veterinary Science · United States
- Species:
- horse
Abstract
Screening of an expression library of Leptospira interrogans with eye fluids from uveitic horses resulted in identification of a novel protein, LruC. LruC is located in the inner leaflet of the leptospiral outer membrane, and an lruC gene was detected in all tested pathogenic L. interrogans strains. LruC-specific antibody levels were significantly higher in eye fluids and sera of uveitic horses than healthy horses. These findings suggest that LruC may play a role in equine leptospiral uveitis.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22237897/