Peer-reviewed veterinary case report
Antibody-based delivery of IL2 and cytotoxics eradicates tumors in immunocompetent mice.
- Journal:
- Molecular cancer therapeutics
- Year:
- 2014
- Authors:
- Gutbrodt, Katrin L et al.
- Affiliation:
- Authors' Affiliations: Department of Chemistry and Applied Biosciences
- Species:
- rodent
Abstract
Antibody-drug conjugates are increasingly being used for cancer therapy, but little is known about their ability to promote anticancer immunity, which may lead to long-lasting remissions. We investigated the therapeutic effect of antibody-based pharmacodelivery of cemadotin, a cytotoxic drug, and IL2, a strong proinflammatory cytokine. Using the F8 antibody, which selectively localizes to the tumor neovasculature, combination treatment led to tumor eradication, in a process dependent on CD8(+) T cells and natural killer cells in the C1498 syngeneic mouse model of acute myelogenous leukemia. The clinical combination of antibody-drug conjugates and antibody-cytokine proteins should be facilitated by their orthogonal toxicity profiles.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24759429/