Peer-reviewed veterinary case report
Antibody escape kinetics of equine infectious anemia virus infection of horses.
- Journal:
- Journal of virology
- Year:
- 2015
- Authors:
- Schwartz, Elissa J et al.
- Affiliation:
- School of Biological Sciences and Department of Mathematics · United States
- Species:
- horse
Abstract
Lentivirus escape from neutralizing antibodies (NAbs) is not well understood. In this work, we quantified antibody escape of a lentivirus, using antibody escape data from horses infected with equine infectious anemia virus. We calculated antibody blocking rates of wild-type virus, fitness costs of mutant virus, and growth rates of both viruses. These quantitative kinetic estimates of antibody escape are important for understanding lentiviral control by antibody neutralization and in developing NAb-eliciting vaccine strategies.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25878104/