Peer-reviewed veterinary case report
Parvovirus vaccine response in dogs with hypothyroidism
By Bergmann, Michèle et al.·Published in Vaccines·2021·Clinic of Small Animal Medicine, LMU Munich, Veterinaerstrasse 13, 80539 Munich, Germany, Germany·View original on Crossref →
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Original publication title: Antibody Response to Canine Parvovirus Vaccination in Dogs with Hypothyroidism Treated with Levothyroxine
- Species:
- dog
Plain-English summary
A group of dogs with hypothyroidism, treated with levothyroxine, were vaccinated against canine parvovirus to see how well they responded compared to healthy dogs. All dogs had antibodies before vaccination, but none of the hypothyroid dogs showed a significant increase in antibody levels after the shot, while a small percentage of healthy dogs did. Both groups experienced mild side effects from the vaccine, but the response to the vaccination was similar for both healthy dogs and those with hypothyroidism. This suggests that dogs with hypothyroidism can be vaccinated without any special concerns.
People also search for: dog hypothyroidism vaccination response · canine parvovirus vaccine side effects · dog with hypothyroidism and vaccines
Abstract
(1) Background: No information is available on how dogs with hypothyroidism (HypoT) respond to vaccination. This study measured pre- and post-vaccination anti-canine parvovirus (CPV) antibodies in dogs with HypoT treated with levothyroxine and compared the results to those of healthy dogs. (2) Methods: Six dogs with HypoT and healthy age-matched control dogs (n = 23) were vaccinated against CPV with a modified-live vaccine. Hemagglutination inhibition was used to measure antibodies on days 0, 7, and 28. The comparison of the vaccination response of dogs with HypoT and healthy dogs were performed with univariate analysis. (3) Results: Pre-vaccination antibodies (≥10) were detected in 100% of dogs with HypoT (6/6; 95% CI: 55.7–100) and in 100% of healthy dogs (23/23; 95% CI: 83.1–100.0). A ≥4-fold titer increase was observed in none of the dogs with HypoT and in 4.3% of the healthy dogs (1/23; CI95%: <0.01–22.7). Mild vaccine-associated adverse events (VAAEs) were detected in 33.3% of the dogs with HypoT (2/6; 95% CI: 9.3–70.4) and in 43.5% (10/23; 95% CI: 25.6–63.2) of the healthy dogs. (4) Conclusions: There was neither a significant difference in the dogs’ pre-vaccination antibodies (p = 1.000), or vaccination response (p = 0.735), nor in the occurrence of post-vaccination VAAEs (p = 0.798). The vaccination response in dogs with levothyroxine-treated HypoT seems to be similar to that of healthy dogs.
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Search related cases →Original publication on Crossref: https://doi.org/10.3390/vaccines9020180