Peer-reviewed veterinary case report
Dog antibody responses after Bordetella bronchiseptica vaccination
By Ellis, John et al.·Published in The Canadian veterinary journal = La revue veterinaire canadienne·2014·Department of Veterinary Microbiology (Ellis, United States·View original on PubMed →
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Original publication title: Antibody responses to Bordetella bronchiseptica in vaccinated and infected dogs.
- Species:
- dog
Plain-English summary
A group of vaccinated and infected dogs were tested to see how well they responded to a new type of vaccine for Bordetella bronchiseptica, which causes kennel cough. The vaccinated dogs showed a strong increase in protective antibodies after receiving the new vaccine, which helps fight off the infection. However, the response varied among client-owned dogs based on their previous vaccination history and exposure to the bacteria. Overall, the new vaccine seemed effective in boosting the dogs' immune response, similar to older vaccines.
People also search for: dog kennel cough vaccine effectiveness · Bordetella bronchiseptica in dogs · vaccinated dog immune response
Abstract
Bordetella bronchiseptica (Bb) whole cell bacterins have been replaced with acelluar vaccines. We evaluated the response to the acellular Bb vaccines in Bb-seropositive commingled laboratory beagles and client-owned dogs with various lifestyles and vaccination histories. A single parenteral dose of the acellular Bb vaccine resulted in consistent anamnestic IgG, and to a lesser, but notable extent, IgA, Bb-reactive antibody responses in the seropositive beagles. Associated with the increase in antibodies measured by enzyme-linked immunosorbent assay (ELISA) was an increase in the complement (C)-dependent IgG antibody mediated bactericidal effect on Bb in vitro. Antibody responses in client-owned dogs were more variable and were dependent upon the vaccination history and serological evidence of previous Bb exposure. Antibodies from vaccinated dogs recognized several Bb proteins, notably P68 (pertactin) and P220 (fimbrial hemagglutinin), the response to which has been shown to be disease-sparing in Bp infections. These antibody responses were similar to those in experimentally infected dogs and in dogs that had received a widely used whole cell bacterin.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25183893/