Peer-reviewed veterinary case report
Anticonvulsant Effects of Combined Treatment with Citicoline and Valproate on the Model of Acute Generalized Convulsions Induced by Pentylenetetrazole in Wistar Rats.
- Journal:
- Bulletin of experimental biology and medicine
- Year:
- 2016
- Authors:
- Karpova, M N et al.
- Affiliation:
- Research Institute of General Pathology and Pathophysiology
- Species:
- rodent
Abstract
We studied anticonvulsant effects of combined treatment with citicoline, a nootropic substance with neuroregenerative and neuroprotective activities, and valproate, an antiepileptic agent widely used in the treatment of epilepsy, on the model of pentylenetetrazole-induced (75 mg/kg, intraperitoneally) acute generalized convulsions in male Wistar rats. Combined treatment with citicoline and valproate in minimum effective doses (70 and 300 mg/kg, respectively) potentiated the anticonvulsant properties of both agents.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/26902360/