Peer-reviewed veterinary case report
Antidepressant behavioral effects of duloxetine and amitriptyline in the rat forced swimming test.
- Journal:
- Acta cirurgica brasileira
- Year:
- 2008
- Authors:
- Menezes, Honório Sampaio et al.
- Affiliation:
- Cardiology University Foundation · Brazil
- Species:
- rodent
Abstract
PURPOSE: To compare the effects of the antidepressant drugs duloxetine and amitriptyline on depressive behaviors in rats. METHODS: Fifteen male Wistar rats were given systemic injections of duloxetine, amitriptyline or saline prior to a Forced Swimming Test (FST). Immobility and number of stops were measured. Data were analyzed by one-way ANOVA and Kruskall-Wallis. RESULTS: Rats given injections of duloxetine displayed fewer stops than the amitriptyline and control group (p< 0.05). The control group and Amitriptyline showed no difference (p=0.8). CONCLUSION: Duloxetine reduced depressive behaviors in the Forced Swimming Test been more effective than amitriptyline.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18797690/