Peer-reviewed veterinary case report
Antidepressant-like activity of icariin mediated by group I mGluRs in prenatally stressed offspring.
- Journal:
- Brain & development
- Year:
- 2017
- Authors:
- Zhang, Xiaoxiao et al.
- Affiliation:
- Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University) · China
- Species:
- rodent
Abstract
OBJECTIVE: The present study was performed to identify antidepressant-like activity of icariin in prenatally stressed male rats. METHODS: The effects of icariin on PRS-induced depression were examined using sucrose preference test (SPT) and forced swimming test (FST) in male offspring, and measuring protein and mRNA expressions of group I mGluRs receptors and EAAT2 via western blotting and quantitative real-time PCR assays. RESULTS: The results indicated that prenatal restraint stress (PRS) resulted in several behavioral anomalies. Treatment with icariin relieved the elevated protein and mRNA levels of group I mGluR receptors as well as the diminished protein and mRNA levels of EAAT2 in the PRS male offspring. CONCLUSIONS: Collectivity, the data support that icariin ameliorates PRS-induced depressive-like behavior via regulating expression of mGluR1, mGluR5 and EAAT2 in the hippocampus.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/28395974/