Peer-reviewed veterinary case report
Antidepressant-Like Effect of 1α-Hydroxyvitamin Don Mice in the Forced Swimming Test.
- Journal:
- Journal of nutritional science and vitaminology
- Year:
- 2017
- Authors:
- Kawaura, Akihiko et al.
- Affiliation:
- Department of Physical Therapy
- Species:
- rodent
Abstract
We examined the effect of 1α-hydroxyvitamin D[1α(OH)D] on mice in the forced swimming test. Intragastric administration of 1.0 μg/kg of 1α(OH)Dreduced immobility time in the forced swimming test. At all concentrations tested (0.5, 1.0, 2.0 μg/kg), 1α(OH)Dhad no effect on locomotor activity, compared with controls. These results suggest that 1α(OH)Dmay have antidepressant-like activity.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/28367930/