Antidiabetic Activity ofSeed-Based Diet on Alloxan-Induced Diabetic Rats.

Abstract

The antidiabetic activity ofseed-based diet on alloxan-induced diabetic rats was investigated. Forty-eight male and female albino rats of four groups were used for this study. Rats were sacrificed on day 28&#x2009;and organs of interest were excised.seed-based diet significantly (&#x2009;<&#x2009;.05) reversed the levels of fasting blood glucose, albumin, globulin, bilirubin, urea, creatinine, Na, and K. In addition, diabetic rats fedseed-based diet had significantly (&#x2009;<&#x2009;.05) increased insulin and glycogen concentrations, activities of hexokinase, catalase, superoxide dismutase, and glutathione peroxidase and the levels of hematological parameters studied. Diabetic rats fed onseed had significantly (&#x2009;<&#x2009;.05) reduced activities of glucose-6-phosphatase and fructose 1,6-diphosphatase and concentration of MDA and reversed activities of AST and GGT; ALP and regeneration of liver, kidney, and pancreas tissues compared favorably with the control group from histological examination results. Consumption of this diet may be useful for diabetes mellitus patients in ameliorating diabetes mellitus and its complications.