Peer-reviewed veterinary case report
Maropitant given before eye drops stops vomiting in healthy cats
By Kanda, Teppei et al.·Published in Journal of feline medicine and surgery·2020·Faculty of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Antiemetic effect of oral maropitant treatment before the administration of brimonidine ophthalmic solution in healthy cats.
- Species:
- cat
Plain-English summary
A group of five healthy cats were given an oral medication called maropitant before receiving eye drops of brimonidine, which can sometimes cause vomiting. The cats that received maropitant did not vomit or retch after the eye drops, while four out of five cats that did not receive maropitant experienced these symptoms. This suggests that maropitant can help prevent vomiting when using brimonidine eye drops without affecting other important body functions.
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Abstract
OBJECTIVES: The aim of this study was to investigate the antiemetic, behavioural and physiological effects of oral maropitant treatment before the administration of brimonidine ophthalmic solution in healthy cats. METHODS: Five cats received oral maropitant 8 mg or no treatment (control) 18 h before the administration of one drop of brimonidine solution in both eyes. Each cat was administered each of the two treatments, with a washout period of 1 week. The incidence of emesis, retching, sialorrhoea and lip-licking after brimonidine administration was recorded, while behavioural and physiological parameters, including heart rate, mean blood pressure, respiratory frequency and rectal temperature, were recorded before and 0, 30, 60, 90, 120, 180 and 240 mins after brimonidine administration. RESULTS: Emesis and retching were not observed when maropitant was administered. However, 4/5 cats exhibited vomiting and retching in the absence of maropitant pretreatment. The incidence of emesis and retching after brimonidine administration was significantly lower in the treatment group than in the control group. Sialorrhoea occurred in one cat in the control group, while all cats showed lip-licking after brimonidine administration. There were no significant differences in the incidence of sialorrhoea and lip-licking between the two groups. Although behaviour scores were comparable between the two groups, those obtained during heart rate, mean blood pressure and respiratory frequency measurements were significantly lower than the baseline scores; this indicated a sedative effect after brimonidine administration. The heart rate and mean blood pressure significantly decreased after brimonidine administration in both groups, while there were no intergroup differences in the heart rate, mean blood pressure, respiratory frequency and rectal temperature. CONCLUSIONS AND RELEVANCE: Oral maropitant treatment before the administration of brimonidine ophthalmic solution in cats can alleviate emesis and retching without affecting the sedative effects of brimonidine and important physiological parameters.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31313970/