Peer-reviewed veterinary case report
Antifungal drugs tested against Malassezia yeast in dogs
By Merkel, Simone et al.·Published in Journal de mycologie medicale·2024·Federal University of Rio Grande do Sul (UFRGS), Brazil·View original on PubMed →
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Original publication title: Antifungal activity of azoles, allylamines, and 8-hidroxiquinolines, alone and in combination, against Malassezia pachydermatis in vitro and in vivo.
- Species:
- dog
Plain-English summary
A group of dogs with skin infections caused by a yeast called Malassezia pachydermatis were treated with different antifungal medications to see which worked best. The most effective treatment was ketoconazole, followed by terbinafine and clioquinol. When these drugs were combined, they showed even better results, especially the combinations of itraconazole with clioquinol or another compound. The study found that these treatments could significantly reduce the yeast infection in dogs, suggesting that clioquinol could be a promising option for treating this type of skin problem.
People also search for: dog skin infection treatment · Malassezia pachydermatis in dogs · antifungal medication for dogs
Abstract
Malassezia pachydermatis is often reported as the causative agent of dermatitis in dogs. This study aims to evaluate the in vitro and in vivo antifungal activity of azoles and terbinafine (TRB), alone and in combination with the 8-hydroxyquinoline derivatives (8-HQs) clioquinol (CQL), 8-hydroxyquinoline-5-(n-4-chlorophenyl)sulfonamide (PH151), and 8-hydroxyquinoline-5-(n-4-methoxyphenyl)sulfonamide (PH153), against 16 M. pachydermatis isolates. Susceptibility to the drugs was evaluated by in vitro broth microdilution and time-kill assays. The Toll-deficient Drosophila melanogaster fly model was used to assess the efficacy of drugs in vivo. In vitro tests showed that ketoconazole (KTZ) was the most active drug, followed by TRB and CQL. The combinations itraconazole (ITZ)+CQL and ITZ+PH151 resulted in the highest percentages of synergism and none of the combinations resulted in antagonism. TRB showed the highest survival rates after seven days of treatment of the flies, followed by CQL and ITZ, whereas the evaluation of fungal burden of dead flies showed a greater fungicidal effect of azoles when compared to the other drugs. Here we showed for the first time that CQL is effective against M. pachydermatis and potentially interesting for the treatment of malasseziosis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38479291/