Peer-reviewed veterinary case report
Antifungal drug response in yeasts from dogs with seborrheic
By Yurayart, Chompoonek et al.·Published in Medical mycology·2013·* Department of Veterinary Microbiology·View original on PubMed →
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Original publication title: Antifungal agent susceptibilities and interpretation of Malassezia pachydermatis and Candida parapsilosis isolated from dogs with and without seborrheic dermatitis skin.
- Species:
- dog
Plain-English summary
A group of dogs with skin issues, including seborrheic dermatitis (a condition that causes flaky skin), had samples taken to check for two types of yeast: Malassezia pachydermatis and Candida parapsilosis. The study found that most of the Malassezia yeast were sensitive to common antifungal medications like itraconazole and ketoconazole, meaning these treatments should work well for dogs with this type of yeast infection. However, a significant number of Candida yeast showed resistance to ketoconazole, which could make treatment more challenging. Overall, itraconazole and ketoconazole remain effective options for treating Malassezia infections in dogs.
People also search for: dog seborrheic dermatitis treatment · antifungal for dog skin infection · yeast infection in dogs treatment
Abstract
Malassezia pachydermatis and Candida parapsilosis are recognized as commensal yeasts on the skin of healthy dogs but also causative agents of eborrheic dermatitis, especially in atopic dogs. We determined and compared the susceptibility levels of yeasts isolated from dogs with and without seborrheic dermatitis (SD) using the disk diffusion method (DD) for itraconazole (ITZ), ketoconazole (KTZ), nystatin (NYS), terbinafine (TERB) and 5-fluorocytosine (5-FC) and the broth microdilution method (BMD) for ITZ and KTZ. The reliability between the methods was assessed using an agreement analysis and linear regression. Forty-five M. pachydermatis and 28 C. parapsilosis isolates were identified based on physiological characteristics and an approved molecular analysis. By DD, all tested M. pachydermatis isolates were susceptible to ITZ, KTZ, NYS and TERB but resistant to 5-FC. Only 46 - 60% of the tested C. parapsilosis isolates were susceptible to KTZ, TERB and 5-FC, but ITZ and NYS were effective against all. By BMD, over 95% of M. pachydermatis isolates were susceptible to KTZ and ITZ with an MIC90 < 0.03 and 0.12 μg/ml, respectively. The frequency of KTZ- and ITZ-resistant C. parapsilosis was 29% and 7%, and the MIC90 values were 1 μg/ml and 0.5-1 μg/ml, respectively. Regarding the agreement analysis, 2.2% of minor errors were observed in M. pachydermatis and 0.2-1% of very major errors occurred among C. parapsilosis. There were no significant differences in the yeast resistance rates between dogs with and without SD. KTZ and ITZ were still efficacious for M. pachydermatis but a high rate of KTZ resistant was reported in C. parapsilosis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23547880/