Peer-reviewed veterinary case report
Antimalarial activity of the novel quinoline/6-thiopurine conjugate in Gallus gallus Linnaeus, infected experimentally by Plasmodium (Novyella) juxtanucleare.
- Journal:
- Chemical biology & drug design
- Year:
- 2009
- Authors:
- Vashist, Usha et al.
- Affiliation:
- Departamento de Biologia · Brazil
- Species:
- bird
Abstract
This study aimed to evaluate the 4-(6'-thiopurine)-7-chloroquinoline, a novel quinoline/6-thiopurine conjugate, for the treatment of Gallus gallus experimentally infected with Plasmodium juxtanucleare, an avian malaria agent. The avian group treated with 4-(6'-thiopurine)-7-chloroquinoline showed a significative parasite clearance and maintained a low level of parasitaemia, when compared with the untreated control group and to the chloroquine treated avian group.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19691466/