Peer-reviewed veterinary case report
Antimalarial chemotherapy: artemisinin-derived dimer carbonates and thiocarbonates.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2014
- Authors:
- Mazzone, Jennifer R et al.
- Affiliation:
- Department of Chemistry · United States
- Species:
- rodent
Abstract
Several 2-carbon-linked trioxane dimer secondary alcohol carbonates 14 and thiocarbonates 15, combined with mefloquine and administered in a low single oral dose, prolonged the survival times of malaria-infected mice much more effectively than the popular monomeric antimalarial drug artemether plus mefloquine. Three dimer carbonates 14 and one dimer thiocarbonate 15 partially cured malaria-infected mice.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24775306/