Peer-reviewed veterinary case report
New treatment tested for drug-resistant eye infections in dogs
By Jang, Je-Hwan et al.·Published in Frontiers in veterinary science·2024·Department of Veterinary Ophthalmology, South Korea·View original on PubMed →
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Original publication title: Antimicrobial activity of cell-free supernatant derived fromSWLA-1 in a novelcanine corneal infection model.
- Species:
- dog
Plain-English summary
A study tested a new treatment for a serious eye infection in dogs caused by a bacteria called Staphylococcus pseudintermedius, which can lead to vision loss or even the need for eye removal. Researchers used a probiotic-derived solution from the SWLA-1 strain, which showed strong ability to kill this bacteria without harming healthy eye cells. The results suggest that this probiotic solution could be a promising alternative for treating resistant infections in dogs.
People also search for: dog eye infection treatment · Staphylococcus pseudintermedius in dogs · probiotic for dog eye problems
Abstract
INTRODUCTION: Canine bacterial keratitis is a corneal infection that causes various symptoms, including visual impairment, and necessitates eye removal in severe cases. Staphylococcus pseudintermedius is a pathogen that causes significant bacterial keratitis in canine patients. Moreover, multi-drug resistant Staphylococcus pseudintermedius (MDRSP) has been reported in both humans and animals. Regarding treatment failure against multi-drug resistant (MDR) pathogens with classic antibiotics, antimicrobial compounds derived from probiotics have been suggested as an alternative approach. METHODS: SWLA-1 strain and its cell-free supernatant (CFS) have previously demonstrated potent antimicrobial activity against various MDR pathogenic bacteria. Based on this finding, we evaluated the anti-staphylococcal activity of CFS derived fromSWLA-1 against MDRSP in a newly established ex vivo canine corneal infection model using fresh canine corneoscleral rims. Additionally, an in vitro cytotoxicity test using human keratocytes was performed. RESULTS AND DISCUSSION: CFS significantly inhibited the growth of MDRSP in the novel ex vivo model and did not exhibit any significant toxicity against keratocytes in vitro. Based on these results, the antimicrobial compounds in CFS show potential as a novel approach for MDR staphylococcal keratitis treatment.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38716232/