Peer-reviewed veterinary case report
Biological surgical mesh with vancomycin or silver fights resistant
By Loureiro MP et al.·2026·- Universidade Positivo·View original on Europe PMC →
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Original publication title: Antimicrobial effect of biological surgical mesh added with vancomycin or silver nanoparticles for multidrug-resistant bacteria: experimental study in rats.
- Species:
- rodent
Plain-English summary
In a study involving rats, researchers looked at a new type of surgical mesh made from cow heart tissue to see if adding vancomycin (an antibiotic) or silver nanoparticles could help prevent infections after surgery. They compared this new mesh to a standard polypropylene mesh and found that the mesh with vancomycin was much better at controlling infections caused by a tough bacteria known as methicillin-resistant Staphylococcus aureus. The mesh with silver nanoparticles did not work as well and showed less effectiveness than the standard mesh. Overall, the results suggest that the mesh with vancomycin could be a promising option for preventing infections, while the silver nanoparticles did not show any benefit in this case.
Abstract
<h4>Introduction</h4>Surgical site infection (SSI) and polypropylene mesh (PPM) infections are recurrent problems in abdominal hernia surgeries, highlighting the need for a new antimicrobial material for surgical repair. The aim of this study was to evaluate the in vivo antimicrobial effect of a new biological mesh made of decellularized bovine pericardium (BP), added with vancomycin (VAN) or silver nanoparticles (AgNPs), as prevention for SSI.<h4>Methods</h4>Thirty-five Wistar rats were divided into four groups: BP C+ (n=9) with BP without additions; PP C+ (n=8) with PPM; BP AgNPs (n=9) with BP added with silver nanoparticles; and BP VAN (n=9) with BP added with vancomycin. The 1 cm² meshes were stitched into the muscle fascia under the subcutaneous tissue of the rats' backs, followed by inoculation with methicillin-resistant Staphylococcus aureus. The animals were observed for 7 days, with subsequent euthanasia, and histological and bacteriological analysis.<h4>Results</h4>The BP VAN group had better infection control compared to the PP C+ and BP AgNPs groups (1x10¹ vs. 1.4x10³CFU/g, p=0.0303; 1x10¹ vs. 1.5x104CFU/g, p<0.0001, respectively). BP AgNPs showed less bacterial reduction compared to BP C+ (p=0.042). In the histological analysis, there was a mild inflammatory reaction in BP VAN, moderate in BP C+, and intense in PP C+ and BP AgNPs.<h4>Conclusion</h4>BP added with vancomycin showed promising antimicrobial action, while the use of silver nanoparticles did not demonstrate efficacy in this study.
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Search related cases →Original publication on Europe PMC: https://europepmc.org/article/MED/41615166