Peer-reviewed veterinary case report
Antimicrobial effects of medium chain triglyceride emulsion on dog
By Laverty, G et al.·Published in The Journal of small animal practice·2015·School of Pharmacy·View original on PubMed →
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Original publication title: Antimicrobial efficacy of an innovative emulsion of medium chain triglycerides against canine and feline periodontopathogens.
Plain-English summary
A study tested a new non-toxic mouthwash made from medium chain triglycerides (ML:8 emulsion) to see how well it could kill harmful bacteria that cause gum disease in dogs and cats. The results showed that this emulsion was just as effective as a common antiseptic mouthwash (chlorhexidine) at killing these bacteria quickly, achieving over 70% kill rate within just five minutes. Additionally, the ML:8 emulsion was less toxic to cells than chlorhexidine, making it a safer option for pets. This new mouthwash could be a promising alternative for keeping your pet's teeth and gums healthy.
People also search for: dog gum disease treatment · cat dental care products · safe mouthwash for pets
Abstract
OBJECTIVES: To test the in vitro antimicrobial efficacy of a non-toxic emulsion of free fatty acids against clinically relevant canine and feline periodontopathogens METHODS: Antimicrobial kill kinetics were established utilising an alamarBlue(®) viability assay against 10 species of canine and feline periodontopathogens in the biofilm mode of growth at a concentration of 0·125% v/v medium chain triglyceride (ML:8) emulsion. The results were compared with 0·12% v/v chlorhexidine digluconate and a xylitol-containing dental formulation. Mammalian cellular cytotoxicity was also investigated for both the ML:8 emulsion and chlorhexidine digluconate (0·25 to 0·0625% v/v) using in vitro tissue culture techniques. RESULTS: No statistically significant difference was observed in the antimicrobial activity of the ML:8 emulsion and chlorhexidine digluconate; a high percentage kill rate (>70%) was achieved within 5 minutes of exposure and was maintained at subsequent time points. A statistically significant improvement in antibiofilm activity was observed with the ML:8 emulsion compared with the xylitol-containing formulation. The ML:8 emulsion possessed a significantly lower (P < 0·001) toxicity profile compared with the chlorhexidine digluconate in mammalian cellular cytotoxicity assays. CLINICAL SIGNIFICANCE: The ML:8 emulsion exhibited significant potential as a putative effective antimicrobial alternative to chlorhexidine- and xylitol- based products for the reduction of canine and feline periodontopathogens.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25728584/