Antimicrobial Evaluation of Chlorophyll-Containing Nettle Extract Both in Free Form and Incorporated into Poly-3-Hydroxybutyrate.

Abstract

This work is devoted to the electrospinning of biocompatible fibrous matrixes for microbial wound therapy. The problem of treating staphylococcal-infected wounds remains urgent. In this study, we propose a new approach to the use of the chlorophyll (Chl) and poly-3-hydroxybutyrate (PHB) composite system in the treatment of infected wounds. The structure and properties of the electrospun polymer matrix based on PHB modified with various concentrations of Chl was investigated by SEM, confocal microscopy, DSC, EPR. The release rate, fluorescence, and antimicrobial activity of Chl incorporated into PHB were studied. The high efficiency of the developed materials was shown with the participation of laboratory animals.