Peer-reviewed veterinary case report
Antibiotic resistance in E. coli from dog urinary infections in South
By Qekwana, Daniel Nenene et al.·Published in BMC veterinary research·2018·Department of Paraclinical Sciences·View original on PubMed →
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Original publication title: Antimicrobial resistance among Escherichia coli isolates from dogs presented with urinary tract infections at a veterinary teaching hospital in South Africa.
- Species:
- dog
Plain-English summary
A study found that about 22% of dogs with urinary tract infections (UTIs) had E. coli bacteria, which can be resistant to many antibiotics. Over the years, the number of E. coli infections in dogs decreased, but the resistance to antibiotics increased, making it harder to treat these infections. Most of the E. coli strains showed resistance to common antibiotics like penicillin and clindamycin, with nearly all being resistant to multiple drugs. This situation raises concerns for dog owners, as it may affect the effectiveness of treatments for UTIs.
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Abstract
BACKGROUND: This study investigated the burden and predictors of canine E. coli urinary tract infections (UTI) and antimicrobial resistance among dogs presented at a veterinary teaching hospital in South Africa, 2007-2012. METHODS: The Cochran-Armitage trend test was used to investigate temporal trends while logistic regression models were used to investigate predictors (age, sex, breed, year) of E. coli infections and antimicrobial resistance (AMR). RESULTS: A total of 22.3% (168/755) of the urinary specimens tested positive for E. coli. A significant (p = 0.0004) decreasing temporal trend in the percentage of E. coli positive isolates was observed over the study period. There were high levels of AMR to penicillin-G (99%), clindamycin (100%), tylosine (95%), cephalothin (84%) but relatively low levels of resistance to enrofloxacin (16%), orbifloxacin (21%). Almost all (98%, 164/167) the isolates exhibited multidrug resistance (MDR), while only 11% (19/167) and 2% (4/167) exhibited extensive drug resistance (XDR) and pan-drug resistance (PDR), respectively. CONCLUSIONS: Although, the risk of E. coli UTI declined during the study period, the risk of AMR increased. The high levels of AMR and MDR as well as the presence of XDR and PDR is concerning as these have the potential of affecting prognosis of UTI treatments.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30064417/