Peer-reviewed veterinary case report
Fluoroquinolone resistance in Pseudomonas aeruginosa from dog
By Rubin, J et al.·Published in Veterinary microbiology·2008·Department of Veterinary Microbiology, Canada·View original on PubMed →
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Original publication title: Antimicrobial resistance and genetic characterization of fluoroquinolone resistance of Pseudomonas aeruginosa isolated from canine infections.
- Species:
- dog
Plain-English summary
A study found that many strains of Pseudomonas aeruginosa, a bacteria that can cause infections in dogs, are resistant to common antibiotics. This was observed in dogs suffering from ear infections (otitis) and skin infections (pyoderma). The researchers tested 106 samples and discovered that most were resistant to multiple antibiotics, including fluoroquinolones, which are often used to treat these infections. This means that standard treatments may not be effective for these types of bacterial infections in dogs. Pet owners should consult their veterinarian for alternative treatment options if their dog has a Pseudomonas infection.
People also search for: dog ear infection treatment · antibiotic resistance in dogs · Pseudomonas aeruginosa in dogs
Abstract
Infections with antimicrobial-resistant bacteria are a great challenge in both human and veterinary medicine. The purpose of this study was to determine antimicrobial susceptibility of 106 strains of Pseudomonas aeruginosa isolated from dogs with otitis and pyoderma from 2003 to 2006 in the United States. Three antimicrobial panels, including 6 classes and 32 antimicrobial agents, were used. A wide range of susceptibility patterns were noted with some isolates being resistant to between 8 and 28 (mean 16) of the antimicrobials tested. Among the beta-lactams, all isolates were resistant to ampicillin, cefoxitin, cefpodoxime, cephalothin and cefazolin followed by amoxicillin/clavulanic acid (99%), ceftiofur (97%), ceftriaxone (39%), cefotaxime (26%), and cefotaxime/clavulanic acid (20%), whereas less than 7% of isolates were resistant to ceftazidime/clavulanic acid, ceftazidime, piperacillin/tazobactam or cefepime. Two isolates were resistant to the carbapenems. Among the quinolones and fluoroquinolones, the most isolates were resistant to naladixic acid (96%), followed by orbifloxacin (52%), difloxacin (43%), enrofloxacin (31%), marbofloxacin (27%), gatifloxacin (23%), levofloxacin (21%), and ciprofloxacin (16%). Among the aminoglycosides, the most resistance was seen to kanamycin (90%), followed by streptomycin (69%), gentamicin (7%), and amikacin (3%). Of the remaining antimicrobials 100% of the isolates were resistant to chloramphenicol followed by tetracycline (98%), trimethoprim/sulfamethoxazole (57%), and sulfisoxazole (51%). Point mutations were present in gyrA, gyrB, parC, and/or parE genes among 34 of the 102 naladixic acid-resistant isolates. Two isolates contained class 1 integrons carrying aadA gene conferring streptomycin and spectinomycin resistance. The findings suggest that many antimicrobial agents commonly used in companion animals may not constitute appropriate therapy for canine pseudomonas infections.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18395369/