Peer-reviewed veterinary case report
Antibiotic resistance in E. coli from dog urinary infections
By Chang, Shao-Kuang et al.·Published in The Journal of veterinary medical science·2015·Graduate Institute of Veterinary Medicine·View original on PubMed →
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Original publication title: Antimicrobial resistance of Escherichia coli isolates from canine urinary tract infections.
- Species:
- dog
Plain-English summary
A group of dogs with urinary tract infections (UTIs) had urine samples tested for a common bacteria called E. coli. The results showed that many of these bacteria were resistant to common antibiotics like oxytetracycline and ampicillin, making treatment more difficult. In fact, a significant number of the bacteria showed resistance to multiple drugs, which is concerning for pet owners. This highlights the importance of working closely with your veterinarian to choose the right treatment for UTIs in dogs, especially in cases where antibiotic resistance may be an issue.
People also search for: dog urinary tract infection treatment · antibiotic resistance in dogs · E. coli UTI in dogs
Abstract
This study determined the antimicrobial resistance profiles of Escherichia coli isolates from dogs with a presumptive diagnosis of urinary tract infection (UTI). Urine samples from 201 dogs with UTI diagnosed through clinical examination and urinalysis were processed for isolation of Escherichia coli. Colonies from pure cultures were identified by biochemical reactions (n=114) and were tested for susceptibility to 18 antimicrobials. The two most frequent antimicrobials showing resistance in Urinary E. coli isolates were oxytetracycline and ampicillin. Among the resistant isolates, 17 resistance patterns were observed, with 12 patterns involving multidrug resistance (MDR). Of the 69 tetracycline-resistant E. coli isolates, tet(B) was the predominant resistance determinant and was detected in 50.9% of the isolates, whereas the remaining 25.5% isolates carried the tet(A) determinant. Most ampicillin and/or amoxicillin-resistant E. coli isolates carried blaTEM-1 genes. Class 1 integrons were prevalent (28.9%) and contained previously described gene cassettes that are implicated primarily in resistance to aminoglycosides and trimethoprim (dfrA1, dfrA17-aadA5). Of the 44 quinolone-resistant E. coli isolates, 38 were resistant to nalidixic acid, and 6 were resistant to nalidixic acid, ciprofloxacin and enrofloxacin. Chromosomal point mutations were found in the GyrA (Ser83Leu) and ParC (Ser80Ile) genes. Furthermore, the aminoglycoside resistance gene aacC2, the chloramphenicol resistant gene cmlA and the florfenicol resistant gene floR were also identified. This study revealed an alarming rate of antimicrobial resistance among E. coli isolates from dogs with UTIs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25720807/