Peer-reviewed veterinary case report
Antibiotic resistance in Staphylococcus pseudintermedius from healthy
By Onuma, Kenta et al.·Published in Veterinary dermatology·2012·Faculty of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Antimicrobial resistance of Staphylococcus pseudintermedius isolates from healthy dogs and dogs affected with pyoderma in Japan.
- Species:
- dog
Plain-English summary
A study found that some dogs with skin infections (pyoderma) in Japan had bacteria called Staphylococcus pseudintermedius that were resistant to common antibiotics. While healthy dogs and those with pyoderma from earlier years responded well to treatments like cefalexin, by 2009, a significant number of dogs with pyoderma showed resistance to these antibiotics, including fluoroquinolones. This means that some infections may not respond to standard treatments as effectively as before. If your dog has a skin infection that isn't improving, it’s important to talk to your vet about the best treatment options.
Abstract
Staphylococcus pseudintermedius strains were isolated from healthy dogs and dogs with pyoderma in 2000-2002 and 2009. All the isolates from dogs with pyoderma in 1999-2000 and from healthy dogs in 2000-2002 and 2009 were susceptible to cefalexin and/or other cephalosporins and oxacillin. However, 7.1-12.5 and 11.4% of S. pseudintermedius isolates from dogs with pyoderma in 2009 were resistant to cephalosporins and oxacillin, respectively. All S. pseudintermedius isolates from dogs with pyoderma in 1999-2000 and those from healthy dogs in 2000-2002 were susceptible to fluoroquinolones; however, 50% of the S. pseudintermedius strains isolated from dogs with pyoderma in 2009 and 30% of the S. pseudintermedius strains isolated from healthy dogs in 2009 were resistant to fluoroquinolones. Of the 21 oxacillin-resistant S. pseudintermedius (MRSP) isolates, 11 carried SCCmec type V and 10 carried hybrid SCCmec types II-III. Staphylococcus pseudintermedius strains that were resistant to only one of three fluoroquinolones had a mutation in the quinolone resistance determination region of grlA, whereas S. pseudintermedius strains that were resistant to two or more fluoroquinolones had mutations in the quinolone resistance determination regions of both grlA and gyrA.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21745248/