Peer-reviewed veterinary case report
Antibiotic resistance in Klebsiella pneumoniae from dogs in Beijing
By Liu, Yanhan et al.·Published in Journal of global antimicrobial resistance·2017·College of Veterinary Medicine, China·View original on PubMed →
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Original publication title: Antimicrobial resistance profiles and genotypes of extended-spectrum β-lactamase- and AmpC β-lactamase-producing Klebsiella pneumoniae isolated from dogs in Beijing, China.
- Species:
- dog
Plain-English summary
A group of dogs in Beijing were found to have a type of bacteria called Klebsiella pneumoniae in their feces and urine, which can cause infections. Many of these bacteria showed resistance to common antibiotics, with over half being resistant to extended-spectrum beta-lactamase (ESBL) and a smaller portion to AmpC beta-lactamase. This means that treating infections caused by these bacteria can be challenging. The study highlights the importance of testing for these resistant strains in dogs to ensure effective treatment options are available.
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Abstract
OBJECTIVES: Klebsiella pneumoniae, which exists in the intestinal and respiratory tracts of humans and animals, is an important conditional pathogen in many animals. The aim of the current study was to investigate the antimicrobial resistance profiles and genotypes of extended-spectrum β-lactamase (ESBL)- and AmpC β-lactamase-producing K. pneumoniae isolated from dogs. METHODS: A total of 285 isolates, collected from faecal and urine samples of diseased dogs in a Veterinary Teaching Hospital in Beijing, were characterised by antimicrobial susceptibility testing and screened for ESBL and AmpC β-lactamase phenotypes. The relevant genes were identified by polymerase chain reaction and sequencing. RESULTS: All K. pneumoniae isolates were susceptible to meropenem, while the rates of resistance to the remaining 27 tested antimicrobials ranged from 24% to 97%. A total of 53% and 18% of K. pneumoniae isolates were positive for ESBL and AmpC β-lactamase production, respectively. ESBL/AmpC-producing strains were significantly resistant to more antimicrobial agents compared non-ESBL/AmpC-producing strains (P<0.05). CTX-M groups 1 and 9, and DHA-1 were the predominant genotypes of the ESBL/AmpC-producing K. pneumoniae isolates. CONCLUSIONS: In conclusion, the high percentage of drug resistance among K. pneumoniae isolates suggests that routine detection of ESBL production by reliable laboratory methods is required in small animal clinical practice.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28735050/