Peer-reviewed veterinary case report
Antibiotic resistance in Clostridium perfringens from Swiss dogs
By Gobeli, S et al.·Published in Schweizer Archiv fur Tierheilkunde·2012·Institute of Veterinary Bacteriology·View original on PubMed →
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Original publication title: Antimicrobial susceptibility of canine Clostridium perfringens strains from Switzerland.
- Species:
- dog
Plain-English summary
A group of dogs with acute diarrhea was tested for a bacteria called Clostridium perfringens, which can cause gastrointestinal issues. The study found that while most strains of this bacteria were still treatable with antibiotics, some showed resistance to tetracycline and decreased effectiveness against metronidazole, a common treatment for dog diarrhea. This suggests that antibiotic resistance is becoming a concern in these cases. It's important for veterinarians to identify the specific bacteria and test for antibiotic resistance before starting treatment to ensure the best outcome for the dog.
People also search for: dog diarrhea treatment · Clostridium perfringens in dogs · antibiotic resistance in dogs
Abstract
Fifty Clostridium perfringens strains were isolated from individual dogs with acute diarrhoea that were not given antibiotics. Toxin types and minimal inhibitory concentrations of 15 antibiotics were determined for each of them. All strains harboured the alpha-toxin gene, 12 of them had both the alpha- and entero-toxin gene and 5 had both the alpha- and beta2-toxin gene. Eighteen percent of the isolates showed resistance to tetracycline and 54 % showed decreased susceptibility to metronidazole which is one of the most frequently used antibiotics in the treatment of canine diarrhoea. Apart from that, all isolates were susceptible to the remaining antibiotics tested. These findings lead to the conclusion that despite a general susceptibility to antibiotics in C. perfringens, resistance is developing in isolates from dogs. Therefore, careful identification of the pathogenic agent and antibiotic susceptibility testing should be performed prior to therapy in order to minimise further selection of antibiotic resistance.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22653699/