Peer-reviewed veterinary case report
Fluoroquinolone antibiotic testing for dog ear infections
By McKay, Lindsay et al.·Published in Journal of the American Animal Hospital Association·2007·Department of Dermatology, United States·View original on PubMed →
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Original publication title: Antimicrobial testing of selected fluoroquinolones against Pseudomonas aeruginosa isolated from canine otitis.
- Species:
- dog
Plain-English summary
A study found that dogs with ear infections caused by Pseudomonas aeruginosa were more likely to respond to marbofloxacin than to enrofloxacin or orbifloxacin. Over a year and a half, researchers tested 100 samples from affected dogs and discovered that marbofloxacin was significantly more effective. This means that if your dog has an ear infection, marbofloxacin might be a better treatment option than the other two medications. It's important to discuss these findings with your veterinarian to ensure your pet gets the most effective care.
People also search for: dog ear infection treatment · marbofloxacin for dogs · enrofloxacin effectiveness in dogs
Abstract
A total of 100 Pseudomonas aeruginosa (P. aeruginosa) isolates were collected over a 1.5-year period from cases of canine otitis. Sensitivities to enrofloxacin, marbofloxacin, and orbifloxacin were determined using minimum inhibitory concentration testing (MICT). Isolates were also tested for sensitivities to enrofloxacin and marbofloxacin using disk-diffusion susceptibility testing (DDST). Isolates were significantly more sensitive to marbofloxacin than to enrofloxacin (z = -4.57; P<0.05) or orbifloxacin (z = -5.02; P<0.05). Agreement was 87% between MICT and DDST for marbofloxacin, with approximately equal numbers of overestimation and underestimation errors. Agreement was 74% between MICT and DDST for enrofloxacin, but DDST tended to overestimate the number of enrofloxacin-susceptible strains. These results suggest that marbofloxacin is more effective against P. aeruginosa than either enrofloxacin or orbifloxacin and that relying on DDST may lead to ineffective enrofloxacin treatment.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17975212/