Peer-reviewed veterinary case report
Antinociceptive effects of A1 and A2 type botulinum toxins on carrageenan-induced hyperalgesia in rat.
- Journal:
- Toxicon : official journal of the International Society on Toxinology
- Year:
- 2013
- Authors:
- Shin, Min-Chul et al.
- Affiliation:
- Kumamoto Health Science University · Japan
- Species:
- rodent
Abstract
We performed a study on the antinociceptive effects of A1 and A2 type (A1LL and A2NTX, respectively) botulinum toxin on carrageenan-induced hyperalgesia in the rat. Both A1LL and A2NTX had antinociceptive effects in the carrageenan-induced inflammatory pain model, reducing the mechanical and thermal hyperalgesia. A2NTX also reduced the increase in c-fos immunoreactivity in L4-L5 spinal segments induced by carrageenan, suggesting that A2NTX inhibits the activation of spinal nociceptive afferent fibers that project to the CNS. Our results indicate that A2NTX may offer a new therapeutic tool to treat inflammatory pain.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23270755/