Peer-reviewed veterinary case report
Antioxidant 21-aminosteroid "U-74389G" ameliorates the short-time effect of hypoxia-reoxygenation on the platelet count in rats.
- Journal:
- Folia medica Cracoviensia
- Year:
- 2015
- Authors:
- Tsompos, Constantinos et al.
- Affiliation:
- Department of Obstetrics & gynecology
- Species:
- rodent
Abstract
AIM: The aim of this experimental study was to examine the effect of the antioxidant drug "U-74389G", on rat model and particularly in a hypoxia-reoxygenation protocol. The beneficial effect or non-effectiveness of that molecule were studied hematologically using blood mean platelet count. Results were that U-74389G administration interacted or not with reoxygenation time decreased the platelet count by 6.12% ± 3.58% (p = 0.0857) and 12.83% ± 5.79% (p = 0.0303) respectively. CONCLUSIONS: U-74389G administration interacted or not with reoxygenation time decreases the platelet count within short-term time of 2 hours by different significance levels.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/26774629/