Peer-reviewed veterinary case report
Butorphanol reduces pain and oxidative stress in dogs after spay
By Gültiken, Nilgün et al.Ā·Published in TheriogenologyĀ·2022Ā·Department of Obstetrics and GynecologyĀ·View original on PubMed ā
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Original publication title: Antioxidant and analgesic potential of butorphanol in dogs undergoing ovariohysterectomy.
- Species:
- dog
Plain-English summary
A group of 27 healthy female dogs undergoing spay surgery (ovariohysterectomy) were given a pain medication called butorphanol either before or during surgery to see if it helped with pain and oxidative stress after the procedure. Pain levels increased shortly after surgery but decreased over time for all dogs, and there was no significant difference in pain scores between the groups. However, dogs that received butorphanol during surgery showed lower levels of oxidative stress markers and higher antioxidant activity in their blood compared to those who received it before surgery or not at all. While butorphanol may not have provided enough pain relief on its own, it did seem to help protect tissues after surgery.
People also search for: dog spay surgery pain relief Ā· butorphanol for dogs Ā· postoperative care for spayed dogs
Abstract
The aim of this study was to evaluate the postoperative analgesic and antioxidant effects of butorphanol given in the preoperative or early postoperative period. Twenty-seven healthy female dogs undergoing ovariohysterectomy were randomly divided into three groups as before surgery group (BSG, n = 7) received butorphanol 30 min before preanesthetic administration, after surgery group (ASG, n = 10) received butorphanol during the last skin suture and the control group (CG, n = 10) received no butorphanol. Pain was assessed with short form of the Glasgow composite pain scale (CMPS-SF). Serum concentration of malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase activities (GPx) were quantified by spectrophotometric methods to assess oxidative stress status. The pain score increased rapidly at 1 h after surgery and then decreased gradually towards to 24 h in all groups. There was no statistical difference among the groups in terms of CMPS-SF scores (P > 0.05). Serum concentration of MDA was lower in ASG than in BSG and CG from 1 h to 24 h after surgery. Serum activity of GPx was higher in ASG than in BSG and CG from 2 h to 24 h (P < 0.05). Serum activity of SOD was higher in ASG than in BSG and CG from 1 h to 24 h after surgery (P < 0.05). Serum SOD activity at different time points in ASG did not differ compared to preoperative level though it decreased significantly from 1 h onwards both in CT and BSG. The results indicate that single butorphanol administration either before or after the operation might not provide sufficient analgesia, however, it seems that it has antioxidant potential and may protect tissues by reducing oxidative stress when administered early postoperative period following ovariohysterectomy.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35849850/