Peer-reviewed veterinary case report
Antioxidant effect of MnTE-2-PyP on lung in asthma mice model.
- Journal:
- TheScientificWorldJournal
- Year:
- 2012
- Authors:
- Terziev, Lyudmil et al.
- Affiliation:
- Pelven Medical University
- Species:
- rodent
Abstract
AIM: To investigate the effects of MnTE-2-PyP on some markers of antioxidant defence system in asthma mice model. MATERIAL AND METHODS: The animals were divided into four groups: group 1, controls; group 2, injected with ovalbumin, group 3, treated with MnTE-2-PyP, and group 4, treated with ovalbumin and MnTE-2-PyP. The activities of superoxide dismutase, catalase, glutathione peroxidase and nonprotein sulfhydryl groups content (NPSH) were determined in lung homogenate. RESULTS: The activities of superoxide dismutase and catalase in group 2 decreased significantly as compared to control group. The decrease of the same enzymes in group 4 was lower and significant as compared to group 2. Changes in the glutathione peroxidase activity showed a similar dynamics. The NPSH groups content decreased in group 2. In group 4 this decrease was relatively lower as compared to group 2. CONCLUSIONS: The application of MnTE-2-PyP mitigated the effects of oxidative stress in asthma mice model.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22654599/