Peer-reviewed veterinary case report
Antioxidant levels in hyperthyroid cats before and after radioiodine
By Branter, E et al.·Published in Journal of veterinary internal medicine·2012·Department of Medical Sciences, United States·View original on PubMed →
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Original publication title: Antioxidant status in hyperthyroid cats before and after radioiodine treatment.
- Species:
- cat
Plain-English summary
A group of hyperthyroid cats were tested for blood antioxidant levels and urinary markers before and after receiving radioiodine treatment. The results showed that while certain antioxidants in the blood were similar to healthy cats, the hyperthyroid cats had higher levels of urinary isoprostanes, indicating oxidative stress. After treatment, these markers returned to normal, suggesting that the radioiodine therapy effectively addressed the oxidative issues caused by hyperthyroidism. This study highlights the importance of monitoring antioxidant levels in hyperthyroid cats and the positive effects of radioiodine treatment.
People also search for: hyperthyroid cat treatment · cat urinary isoprostanes · radioiodine therapy for cats
Abstract
BACKGROUND: Reversible antioxidant depletion is found in hyperthyroid humans, and antioxidant depletion increases the risk of methimazole toxicosis in rats. OBJECTIVES: To determine whether abnormalities in concentrations of blood antioxidants or urinary isoprostanes were present in hyperthyroid cats, and were reversible after radioiodine treatment. To determine whether or not antioxidant abnormalities were associated with idiosyncratic methimazole toxicosis. ANIMALS: Hyperthyroid cats presented for radioiodine treatment (n = 44) and healthy mature adult control cats (n = 37). METHODS: Prospective, controlled, observational study. Red blood cell glutathione (GSH), plasma ascorbate (AA), plasma free retinol (vitamin A), α-tocopherol (vitamin E), and urinary free 8-isoprostanes in hyperthyroid cats were compared to healthy cats and to hyperthyroid cats 2 months after treatment. RESULTS: Blood antioxidants were not significantly different in hyperthyroid cats (mean GSH 1.6 ± 0.3 mM; AA 12.8 ± 4.9 μM, and vitamin E, 25 ± 14 μg/mL) compared to controls (GSH 1.4 ± 0.4 mM; AA 15.0 ± 6.6 μM, and vitamin E, 25 ± 17 μg/mL). Urinary isoprostanes were increased in hyperthyroid cats (292 ± 211 pg/mg creatinine) compared to controls (169 ± 82 pg/mg; P = .006), particularly in hyperthyroid cats with a USG < 1.035. Plasma free vitamin A was higher in hyperthyroid cats (0.54 ± 0.28 μg/mL versus 0.38 ± 0.21 in controls; P = .007). Both abnormalities normalized after radioiodine treatment. No association was found between oxidative status and prior idiosyncratic methimazole toxicosis. CONCLUSION AND CLINICAL IMPORTANCE: Increased urinary isoprostane could reflect reversible renal oxidative stress induced by hyperthyroidism, and this requires additional evaluation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22428726/