Peer-reviewed veterinary case report
Antithrombotic activity of a new benzimidazole derivative in the thrombosis model in mice.
- Journal:
- Bulletin of experimental biology and medicine
- Year:
- 2014
- Authors:
- Smirnov, A V et al.
- Affiliation:
- Department for Pathological Anatomy
- Species:
- rodent
Abstract
Antithrombotic activity of a new benzimidazole derivative RU-891, characterized by antiaggregant activity, vs. reference drug acetylsalicylic acid was studied on the epinephrinecollagen thrombosis model in mice. Antithrombotic activity of RU-891 3-fold surpassed that of the reference drug. Histological studies showed that RU-891 significantly reduced the relative and mean areas of thrombi in sections of mouse lungs in comparison with the control.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25257418/