Peer-reviewed veterinary case report
Antiviral activity of itraconazole against type I feline coronavirus infection.
- Journal:
- Veterinary research
- Year:
- 2019
- Authors:
- Takano, Tomomi et al.
- Affiliation:
- School of Veterinary Medicine · Japan
- Species:
- cat
Abstract
Feline coronaviruses (FCoVs) are the causative agents of severe systemic disease (feline infectious peritonitis: FIP) in domestic and wild cats. FCoVs have been classified into serotypes I and II. Type I FCoV is the dominant serotype (approximately 70-90%) worldwide. Therefore, it is necessary to provide antiviral agents for type I FCoV infection. In this study, we demonstrated that itraconazole (ICZ), practically used for fungal infections in cats, inhibits the type I FCoV infection. ICZ also exhibited antiviral effect in cells after viral infection, suggesting that ICZ could potentially be used as a therapeutic.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/30658691/