Peer-reviewed veterinary case report
Extract shows antiviral effects against feline coronavirus
By Chou, Ai-Ai et al.·Published in The veterinary quarterly·2024·Department of Veterinary Medicine·View original on PubMed →
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Original publication title: Antiviral activity ofextract against feline coronavirus.
- Species:
- cat
Plain-English summary
A study found that an extract from a plant showed promise in treating feline infectious peritonitis (FIP), a serious illness caused by a mutated feline coronavirus in cats. The extract was able to reduce the virus's ability to multiply and block its effects during infection. When used alongside other antiviral medications, it worked even better than when used alone. This suggests that the plant extract could be a helpful addition to treatments for FIP, which is often difficult to manage.
People also search for: cat FIP treatment · feline coronavirus medication · antiviral for cats with FIP
Abstract
Feline infectious peritonitis (FIP) is a fatal illness caused by a mutated feline coronavirus (FCoV). This disease is characterized by its complexity, resulting from systemic infection, antibody-dependent enhancement (ADE), and challenges in accessing effective therapeutics. Extract derived from(L.) R. Wilczek (VRE) exhibits various pharmacological effects, including antiviral activity. This study aimed to investigate the antiviral potential of VRE against FCoV, addressing the urgent need to advance the treatment of FIP. We explored the anti-FCoV activity, antiviral mechanism, and combinational application of VRE by means ofantiviral assays. Our findings reveal that VRE effectively inhibited the cytopathic effect induced by FCoV, reduced viral proliferation, and downregulated spike protein expression. Moreover, VRE blocked FCoV in the early and late infection stages and was effective underADE infection. Notably, when combined with VRE, the polymerase inhibitor GS-441524 or protease inhibitor GC376 suppressed FCoV more effectively than monotherapy. In conclusion, this study characterizes the antiviral property of VRE against FCoV, and VRE possesses therapeutic potential for FCoV treatment.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38712855/