Peer-reviewed veterinary case report
Antiviral effect of sinefungin on in vitro growth of feline herpesvirus type 1.
- Journal:
- The Journal of antibiotics
- Year:
- 2019
- Authors:
- Kuroda, Yudai et al.
- Affiliation:
- Joint Faculty of Veterinary Medicine · Japan
- Species:
- cat
Abstract
Feline herpesvirus type 1 (FHV-1) causes a potentially fatal disease in cats. Through the use of virus inhibition and cytotoxicity assays, sinefungin, a nucleoside antibiotic, was assessed for its potential to inhibit the growth of FHV-1. Sinefungin inhibited in vitro growth of FHV-1 most significantly over other animal viruses, such as feline infectious peritonitis virus, equine herpesvirus, pseudorabies virus and feline calicivirus. Our results revealed that sinefungin specifically suppressed the replication of FHV-1 after its adsorption to the host feline kidney cells in a dose-dependent manner without obvious cytotoxicity to the host cells. This antibiotic can potentially offer a highly effective treatment for animals infected with FHV-1, providing alternative medication to currently available antiviral therapies.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/31534199/