Peer-reviewed veterinary case report
Stem cells from fat tissue may fight cat calicivirus and herpesvirus
By Teshima, Takahiro et al.·Published in Viruses·2022·Department of Veterinary Clinical Medicine, Japan·View original on PubMed →
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Original publication title: Antiviral Effects of Adipose Tissue-Derived Mesenchymal Stem Cells Secretome against Feline Calicivirus and Feline Herpesvirus Type 1.
- Species:
- cat
Plain-English summary
A study looked at how mesenchymal stem cells (MSCs) from cats might help fight off common viruses that cause upper respiratory issues, specifically feline calicivirus (FCV) and feline herpesvirus type 1 (FHV1). These viruses can lead to serious conditions like gingivostomatitis in cats. The researchers found that the substances secreted by these MSCs didn't stop the viruses from entering cells, but they did reduce the viruses' ability to replicate. This suggests that MSCs could be a potential treatment option for cats suffering from viral infections.
People also search for: cat upper respiratory infection treatment · feline calicivirus symptoms · gingivostomatitis in cats treatment
Abstract
Mesenchymal stem cells (MSCs) have excellent anti-inflammatory and immunomodulatory capabilities and therapeutic effects in some viral diseases. The therapeutic impact of MSCs mainly relies on the paracrine effects of various secreted substances. Feline calicivirus (FCV) and feline herpesvirus type 1 (FHV1) are common and highly prevalent pathogens causing upper respiratory diseases, and FCV is associated with gingivostomatitis in cats. Recently, feline MSC treatment has been reported to improve the clinical symptoms of feline chronic gingivostomatitis, but the antiviral effects of feline MSCs on FCV and FHV1 are not known. In this study, we evaluated the antiviral efficacy of using feline MSC secretome as a conditioned medium on FCV and FHV1 viral replication in Crandell-Reese feline kidney (CRFK) cells, and RNA sequencing was used to analyze how the CRFK cells were altered by the MSC secretomes. The feline MSC secretome did not inhibit FCV or FHV1 viral entry into the CRFK cells but had antiviral effects on the replication of both FCV and FHV1 in a dose-dependent manner.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36016308/