Peer-reviewed veterinary case report
Dog with malignant sweat gland tumor affecting two cell types
By Matsumoto, Kana et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2023·Department of Applied Science, Japan·View original on PubMed →
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Original publication title: Apocrine carcinoma-and-malignant myoepithelioma in a dog: a case of simultaneous malignant progression of both luminal epithelium and myoepithelium.
- Species:
- dog
Plain-English summary
A 9-year-old male Boxer developed a skin tumor on his jaw that was growing aggressively. The tumor had two types of abnormal cells, which changed from less severe to more aggressive forms over time. After testing, the tumor was diagnosed as a rare type of cancer involving both sweat gland cells and myoepithelial cells (cells that help support gland function). Unfortunately, this type of tumor can be serious, and treatment options may vary depending on the specific case.
People also search for: Boxer skin tumor · dog jaw cancer treatment · malignant myoepithelioma in dogs
Abstract
A 9-y-old male Boxer dog developed a mandibular skin tumor, which histologically had a locally invasive growth pattern composed of bilayered structures of inner eosinophilic cuboidal tumor cells and outer clear polygonal tumor cells with cytoplasm containing glycogen granules. Both cell populations gradually changed from low-grade morphologic features to highly anaplastic ones. Immunohistochemically, the eosinophilic tumor cells were positive for cytokeratin 8, a useful marker for luminal epithelial cells. In contrast, the clear tumor cells expressed several myoepithelial markers, including α-smooth muscle actin, p63, and cytokeratin 14. Based on these histologic and immunohistochemical characteristics, we diagnosed this apocrine sweat gland tumor as a carcinoma-and-malignant myoepithelioma with high-grade transformation of both luminal and myoepithelial cells. Our case may be a helpful reference for the histogenesis of carcinoma-and-malignant myoepithelioma, in which both the luminal epithelial and myoepithelial components are malignant.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37786275/