Peer-reviewed veterinary case report
Proteins linked to cell death predict survival in dog skin mast cell
By Barra, C N et al.·Published in Veterinary and comparative oncology·2018·Departamento de Patologia, Brazil·View original on PubMed →
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Original publication title: Apoptotic intrinsic pathway proteins predict survival in canine cutaneous mast cell tumours.
- Species:
- dog
Plain-English summary
A study looked at dogs with skin tumors called mast cell tumors (MCTs), which can be aggressive and often come back after treatment. The researchers found that certain proteins in the tumors could help predict how long a dog might survive after treatment. Specifically, high levels of a protein called BAX were linked to a higher chance of dying sooner, while other proteins provided additional insights into the tumor's behavior. This information could help veterinarians better understand the severity of MCTs and tailor treatment plans for affected dogs.
People also search for: dog mast cell tumor prognosis · canine skin tumor treatment · mast cell tumor survival rate
Abstract
Mast cell tumours (MCTs) are the most frequent canine round cell neoplasms and show variable biological behaviours with high metastatic and recurrence rates. The disease is treated surgically and wide margins are recommended. Adjuvant chemotherapy and radiotherapy used in this disease cause DNA damage in neoplastic cells, which is aimed to induce apoptotic cell death. Resisting cell death is a hallmark of cancer, which contributes to the development and progression of tumours. The aim of this study was to investigate the expression of the proteins involved in the apoptotic intrinsic pathway and to evaluate their potential use as prognostic markers for canine cutaneous MCTs. Immunohistochemistry for BAX, BCL2, APAF1, Caspase-9, and Caspase-3 was performed in 50 canine cases of MCTs. High BAX expression was associated with higher mortality rate and shorter survival. BCL2 and APAF1 expressions offered additional prognostic information to the histopathological grading systems. The present results indicate that variations in the expression of apoptotic proteins are related to malignancy of cutaneous MCTs in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28608404/