Peer-reviewed veterinary case report
Using blood tests to check for pancreatitis in cats that are very
By Krasztel, Magdalena Maria et al.·Published in BMC veterinary research·2021·Institute of Veterinary Medicine·View original on PubMed →
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Original publication title: Application of a complete blood count to screening lethargic and anorectic cats for pancreatitis.
- Species:
- cat
Plain-English summary
A group of cats showing signs of lethargy and not eating for at least two days were tested for pancreatitis, a serious health issue. Researchers found that certain blood test results could help identify cats at risk for this condition without needing expensive imaging or specialized tests. Specifically, measurements of white blood cells and other blood components were linked to the likelihood of pancreatitis. This new method could help vets quickly screen cats and determine if further testing is needed, potentially leading to faster treatment.
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Abstract
BACKGROUND: Feline pancreatitis (FP) is an important health problem of cats. Its diagnostics is based on the combination of quantification of serum pancreatic lipase immunoreactivity (fPLI) and abdominal ultrasonography (AUS). These modalities allow for establishing highly specific diagnosis, however they are relatively expensive and time-consuming. On the other hand, a screening test of high sensitivity which would allow to rule out FP on the first visit without a considerable increase of costs would be clinically useful. To evaluate accuracy of nonspecific inflammatory biomarkers based on complete blood count (CBC) in diagnosing FP 73 client-owned cats with signs of lethargy and reduced appetite lasting for at least 2 days before presentation were enrolled in the cross-sectional study. They were examined with fPLI assay and AUS and classified as cats with very low risk of FP when fPLI ≤3.5 μg/L and AUS negative for FP, or as cats with increased risk of FP in the case of any other combination of results. Then, 7 various CBC measurements were measured in each cat and linked to the risk of FP using the multivariable logistic regression. RESULTS: Five CBC measurements turned out to be significantly associated with the risk of FP - total leukocyte count (WBC; crude odds ratio(OR) = 12.2; CI 95%: 1.52, 98.5), total neutrophil count (OR = 5.84; CI 95%: 1.22, 27.9), band neutrophil count (BNC; OR = 6.67; CI 95%: 1.98, 22.4), neutrophil-to-lymphocyte ratio (OR = 3.68; CI 95%: 1.25, 10.9), and eosinophil count (EC; OR = 0.34; CI 95%: 0.12, 0.96). The model based on WBC, BNC, and EC proved to have at least fair diagnostic potential (area under ROC curve 82.7%; CI 95%: 72.8%, 92.5%). When WBC <  18 G/L, BNC <  0.27 G/L, and EC >  0.3 G/L was considered as a negative result, and any other combination as the positive result, the CBC model had high sensitivity (91.8%; CI 95%: 80.8%, 96.8%) at a relatively low specificity (58.3%; CI 95%: 38.8%, 75.5%). CONCLUSION: The combination of three CBC measurements is an immediately available and fairly accurate screening method for identification of lethargic and anorectic cats with increased risk of FP.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34895249/